Papers and references
Current and previous versions of the EmbryoScope© have been used and tested by several researchers. Some of the work has been published and presented as oral and poster presentations at conferences worldwide. Click on the PDF link to download PDF-versions.
Upcoming at ESHRE 2010
Oral Abstract - Tuesday, 29 June 2010 15:15 Hall 8a
Exact timing analysis for first embryo cleavage strongly correlates with successful implantation; a novel potential tool for embryo selection
Javier Herrero, Alberto Tejera, Niels Ramsing, M Jose de los Santos, Laura Escrich, Marcos Meseguer
Instituto Valenciano de Infertilidad, University of Valencia. Spain.Unisense Fertilitech, Aahrus, Denmark
Oral abstract - Monday June 28 10:00 AM
The quantification of the oocyte quality through respiration patterns correlates oxygen consumption with fertilization and subsequent implantation
Alberto Tejera, Javier Herrero, Niels Ramsing, Nicolas Garrido, Noelia Grau, Marcos Meseguer.
Instituto Valenciano de Infertilidad, University of Valencia. Spain.
Unisense Fertilitech, Aahrus, Denmark
Morphometric variations and differences in embryo cleavage kinetics associated with fertilization procedure: classic IVF vs. ICSI.
Cruz M, Meseguer M, Pérez-Cano I, Muñoz M, Gundersen J, Garrido NInstituto Universitario IVI Valencia, IVI Alicante, Spain
Unisense FertiliTech, Aarhus, Denmark
Time lapse video analysis provide precise division kinetics of cultured embryos which corellates with blastocyst formation and quality.
Cruz M, Garrido N, Pérez-Cano I, Muñoz M, Betersen J, Meseguer M
Instituto Universitario IVI Valencia, IVI Alicante, Spain. Unisense FertiliTech, Aarhus, Denmark
Published article
- Scott, L., Berntsen, J., Davies, D., Gundersen, J., Hill, J., and Ramsing, N.Symposium: Innovative techniques in human embryo viability assessment. Human oocyte respiration-rate measurements - potential to improve oocyte and embry selection? Reproductive Biomedicine online 17 (4), 2008
- Scott, L., Ramsing, N.B. 2007. Oocyte and embryo respiration rate measurements in a clinical setting - Potential to improve embryo selection? The Clinical Embryologist 10(2):5-9
- Ottosen, L.D.M., Hindkjær, J., Lindenberg, S. Ingerslev, H.J. 2007. Murine pre-embryo oxygen consumption and developmental competence. Journal of Assisted Reproduction and Genetics. DOI - 10.1007/s10815-007-9138-5 (Entrez)
- Lopes, A.S., Wrenzycki, C. Ramsing, N.B., Herrmann, D., Niemann, H., Løvendahl, P., Greve, T., Callesen, H. 2007. Respiration rates correlate with mRNA expression of G6PD and GLUT1 genes in individual bovine in vitro-produced blastocysts. Theriogenology 68:223–236 (Entrez)
- Lopes, A.S., Greve, T. and Callesen, H. 2007. Quantification of embryo quality by respirometry. Theriogenology 67(1):21-31 (Entrez)
- Lopes, A.S., Madsen, S.E., Ramsing, N.B., Løvendahl, P., Greve, T. and Callesen, H. 2007. Investigation of respiration of individual bovine embryos produced in vivo and in vitro and correlation with viability following transfer. Human Reproduction 22:558-566 (Entrez)
- Lopes, A.S., Larsen, L.H., Ramsing, N.B., Løvendahl, P., Räty, M., Peippo, J., Greve, T., and Callesen, H. 2005. Respiration rates of individual bovine IVP embryos measured with a novel, non-invasive and rapid microsensor system. Reproduction 130:669-679 (Entrez).
Abstracts
Upcoming at ESHRE 2010
Oral Abstract - Tuesday, 29 June 2010 15:15 Hall 8a
Exact timing analysis for first embryo cleavage strongly correlates with successful implantation; a novel potential tool for embryo selection
Javier Herrero, Alberto Tejera, Niels Ramsing, M Jose de los Santos, Laura Escrich, Marcos Meseguer
Instituto Valenciano de Infertilidad, University of Valencia. Spain.Unisense Fertilitech, Aahrus, Denmark
Oral abstract - Monday June 28 10:00 AM
The quantification of the oocyte quality through respiration patterns correlates oxygen consumption with fertilization and subsequent implantation
Alberto Tejera, Javier Herrero, Niels Ramsing, Nicolas Garrido, Noelia Grau, Marcos Meseguer.
Instituto Valenciano de Infertilidad, University of Valencia. Spain.
Unisense Fertilitech, Aahrus, Denmark
Morphometric variations and differences in embryo cleavage kinetics associated with fertilization procedure: classic IVF vs. ICSI.
Cruz M, Meseguer M, Pérez-Cano I, Muñoz M, Gundersen J, Garrido NInstituto Universitario IVI Valencia, IVI Alicante, Spain
Unisense FertiliTech, Aarhus, Denmark
Time lapse video analysis provide precise division kinetics of cultured embryos which corellates with blastocyst formation and quality.
Cruz M, Garrido N, Pérez-Cano I, Muñoz M, Betersen J, Meseguer M
Instituto Universitario IVI Valencia, IVI Alicante, Spain. Unisense FertiliTech, Aarhus, Denmark
2007
- Automated detection of cell division and movement in time-lapse images of developing bovine embryos can improve selection of viable embryos.
Ramsing, N.B., Berntsen, J., and Callesen, H.
Abstract submitted for oral presentation at ASRM 2007 63rd Annual Meeting, Washington DC, USA. - Respiration measurements of human oocytes correlate with oocyte competence and may be a future means of selection for enhanced outcome. Scott, L., DeLegge, K., Berntsen, J., Hill, J., and Ramsing, N.
Abstract submitted for oral presentation at ASRM 2007 63rd Annual Meeting, Washington DC, USA. - Respiration rates of human oocytes are stage specific and correlate with in vitro development: A potential non-invasive selection method.
L. Scott, K. Delegge, T O'Leary, J. Berntsen, H., Plougsgard, N. Ramsing.
Poster presentation at the ESHRE 2007 23rd Annual Meeting, Lyon, France.
2006
- Embryo quality assessment by automated respiration rate measurements and quantitative image analysis of time-lapse images.
Ramsing, N.B. and Callesen, H.
Oral presentation at FIGO 18th World Congress of Gynecology and Obstetrics 5-10 November 2006 Kuala Lumpur, Malaysia. PDF - Detecting timing and duration of cell divisions by automatic image analysis may improve selection of viable embryos.
Reference: Ramsing, N.B., Callesen, H. 2006. Fertility and sterility 88(suppl.2):S88, O-205.
Oral presentation at American Society for Reproductive Medicine Annual Meeting. 21-25 October New Orleans, USA PDF - Embryo quality assessments by respiration rate measurements and image analysis of time-lapse images during embryo development.
Ramsing, N.B., Scott, L. and Callesen, H.
Oral presentation at the Alpha Biennial Conference, 15-17 September 2006, Lucerne Switzerland (nominated for best presentation) PDF - Embryo Quality Assessment by Respiration Rate Measurements and Image Analysis of Time-Lapse Images During Embryo Development.
Gundersen, J.K., Ramsing, N.B. and Callesen, H.
Presentation at 17th Nordic Fertility Society Conference, 2-5 August 2006 Dipoli, City of Espoo, Finland PDF - Oocyte and embryo respiration rate measurements in a clinical setting - potential to improve embryo selection?
Reference: Scott, L., DeLegge, K., Hill, J., Ramsing, N.B. 2006. Human reproduction 21(suppl. 1):i48, O-125
Oral presentation (Dr. Lynette Scott) at European Society of Human Reproduction and Embryology 22nd Annual Meeting, 18-21 June 2006 Prague, Czech Republic (nominated for the Established Clinician Award) PDF - Relationship between respiration rates and mRNA expression of G6PD and Glut-1 genes in individual blastocysts produced in vitro.
Reference: Lopes, A., Wrenzycki, C., Ramsing, N.B., Hermann, D., Niemann, H., Greve, T., Callesen, H. 2006. Human reproduction 21(suppl. 1):i49, O-126
Oral presentation (Dr. Ana Lopes) at European Society of Human Reproduction and Embryology 22nd Annual Meeting, 18-21 June 2006 Prague, Czech Republic. PDF - Automated image analysis quantifies blastomere activity in time-lapse images to detect onset and duration of cell division during embryo development.
Reference: Ramsing, N.B. and Callesen, H. 2006. Human reproduction 21(suppl. 1):i157, P-410.
Poster presentation at European Society of Human Reproduction and Embryology 22nd Annual Meeting, 18-21 June 2006 Prague, Czech Republic.
2005
- First pregnancies after transfer of bovine in-vivo embryos characterized by nanorespirometry
Lopes A.S., Madsen S.E., Ramsing N.B. , Larsen L.H., Greve T. and Callesen H.
AETE, Association Europeenne de Transfert Embryonnaire 21th Scientific Meeting of the European Embryo Transfer Association September 09th – 10th, 2005 Keszthely, Hungary. PDF - Improved embryo selection using embryo respirometry
Henrik Callesen, Danish Institute of Agricultural Sciences, DK-8830 Tjele, Denmark
Oral presentation at the 21'st Annual Meeting of The European Society of Human Reproduction and Embryology, June 19-22, 2005, Copenhagen. PDF - Embryo Respirometry – a novel technique to measure respiration rates of individual embryos
Callesen, H.; Larsen, L.H.; Damgaard, L.R.; Gundersen, J.K.; Lopes, A.S.; Greve, T. and Ramsing, N.B.
Invited oral presentation at Dansk Fertilitetsselskabs Årsmøde 2005, March 12-13, 2005, Klarskovgård, Denmark. PDF - Correlation between oxygen respiration rates and morphology, sex, diameter and developmental stage of single bovine IVP-embryos.
A.S. Lopes, N. Ramsing, L.H. Larsen, M. Räty, J. Peippo, T. Greve and H. Callesen
Poster presentation at The 31st Annual Conference of The International Embryo Transfer Society, January 9-11, 2005, Copenhagen, Denmark. PDF
- The poster was selected for oral presentation in the IETS Foundation student competition awards. The oral presentation and poster by A. Lopes, subsequently won the First Prize in this competition. - Differences in respiration rates between in vivo and in vitro produced bovine embryos. Lopes A.S., Madsen S.E., Ramsing N.B., Larsen L.H., Greve T. and Callesen H.
Poster presentation at The 32st Annual Conference of The International Embryo Transfer Society, January 8-10, 2005, Orlando, Florida. PDF - Embryo Respirometry – A novel technique to improve embryo selection in IVF procedures by measuring respiration rates of individual embryos
Henrik Callesen, Lars Hauer Larsen, Lars Damgaard, Ana Sofia Lopes, Torben Greve and Niels Birger Ramsing.
Oral presentation at The XVI Nordic IVF Meeting. Organized by the Nordic Fertility Society, January 3-6 2005 in Åre, Sweden. PDF
- The presentation by N.B. Ramsing received the First prize, i.e. the Ferring award for the best presentation and abstract of the conference.
